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Hormonal & Fertility Support · 10mg
Janoshik-tested · 10 vials per kit
Kisspeptin is an endogenous neuropeptide studied in preclinical and clinical research for its central role in reproductive endocrinology. Research has examined its potential to activate GnRH neurons, stimulate LH and FSH secretion, regulate the hypothalamic-pituitary-gonadal axis, and modulate reproductive behavior. Studies have explored applications in hypogonadotropic hypogonadism, fertility research, and puberty regulation models.
≥98%
Purity
Lyophilised
Format
2–3 wks
Arrival
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Research Use Only — Disclaimer
This product is intended solely as a research chemical for laboratory and scientific study purposes only. It is not approved by the TGA or any regulatory body for human or animal consumption, therapeutic use, or clinical application. The information provided on this website is for educational purposes only. Handling must be limited to suitably qualified professionals operating within applicable laws and regulations. This product is not classified as a drug, food, cosmetic, or medicinal product and must not be used or labelled as such. By purchasing, you confirm you are a qualified research professional and accept full responsibility for compliance with all relevant laws in your jurisdiction.
Kisspeptin
Kisspeptin-10 (Metastin)
Kisspeptin-10 is the 10-amino-acid C-terminal bioactive fragment of kisspeptin-54, a neuropeptide encoded by the KISS1 gene expressed predominantly in arcuate and anteroventral periventricular nucleus neurons of the hypothalamus. Originally discovered as a metastasis suppressor gene product (hence 'metastin'), kisspeptins were subsequently identified as the master upstream regulators of the hypothalamic-pituitary-gonadal (HPG) axis.
Kisspeptin acts at KISS1R (GPR54), a Gq-protein-coupled receptor expressed on GnRH neurons. Kisspeptin-GnRH neuron signalling triggers powerful, pulsatile GnRH release, which then drives LH and FSH secretion from the anterior pituitary. This positions kisspeptin as the ultimate gatekeeper of reproductive endocrine function — puberty onset, ovulatory cycles, seasonal reproduction, and testosterone production are all regulated through kisspeptin neurons. Oestrogen, testosterone, and metabolic signals (leptin, energy status) converge on kisspeptin neurons to modulate HPG axis output.
GnRH/LH stimulation, reproductive endocrinology, HPG axis research, hypogonadotrophic hypogonadism, puberty and fertility research, testosterone axis stimulation protocols. Kisspeptin-10 infusion in healthy males produces acute LH pulses and testosterone elevation in a manner dependent on intact GnRH signalling, making it a useful research tool for HPG-axis pharmacology.
Key References
For research reference only. All information pertains to preclinical or published human trial data. Not intended as medical advice. This product is for research use only.
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