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Regenerative & Anti-Aging · 50mg + 20mg
Janoshik-tested · 10 vials per kit
GHK-Cu is a tripeptide-copper complex studied in preclinical research for its multi-target biological activity. Research has examined its potential to stimulate fibroblast proliferation, promote collagen, elastin, and glycosaminoglycan synthesis, and modulate extracellular matrix remodelling. Studies have explored anti-inflammatory effects, angiogenesis promotion, accelerated wound healing, and antioxidant activity through reactive oxygen species scavenging, with dermatological applications for skin barrier improvement and wrinkle reduction.
Blended compound — purity note
Peptide blends are not tested for combined purity as a single compound. However, every component is sourced from the same supplier as our individual peptide products, all of which carry valid Janoshik Analytical COAs. Those certificates apply equally to the same peptides in this blend. View individual COAs →
≥98%
Purity
Lyophilised
Format
2–3 wks
Arrival
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Research Use Only — Disclaimer
This product is intended solely as a research chemical for laboratory and scientific study purposes only. It is not approved by the TGA or any regulatory body for human or animal consumption, therapeutic use, or clinical application. The information provided on this website is for educational purposes only. Handling must be limited to suitably qualified professionals operating within applicable laws and regulations. This product is not classified as a drug, food, cosmetic, or medicinal product and must not be used or labelled as such. By purchasing, you confirm you are a qualified research professional and accept full responsibility for compliance with all relevant laws in your jurisdiction.
GHK-Cu
Copper Tripeptide-1
GHK-Cu (glycyl-L-histidyl-L-lysine : copper 2+) is a naturally occurring copper-binding tripeptide found in human plasma, urine, and saliva. First isolated by Loren Pickart in 1973 from plasma shown to stimulate liver tissue repair, its plasma concentration is approximately 200 ng/mL at age 20, declining to under 80 ng/mL by age 60 — a reduction correlated with reduced tissue repair capacity.
GHK-Cu promotes collagen, elastin, and glycosaminoglycan (including hyaluronic acid) synthesis in fibroblasts. It activates matrix metalloproteinases (MMP-1, 2, 9) for clearance of damaged tissue proteins while simultaneously upregulating their inhibitors (TIMPs) — a coordinated remodelling rarely seen in wound biology. Growth factor upregulation includes TGF-β1, FGF, and VEGF. The copper component is essential for lysyl oxidase activity (collagen and elastin crosslinking) and superoxide dismutase function.
Preclinical studies have demonstrated GHK-Cu's effects on skin tightening and elasticity, hair follicle enlargement, wound contraction, and anti-inflammatory activity. Microarray analyses of GHK-Cu-treated cells show upregulation of over 50 antioxidant and repair genes. Topical application remains the most studied route in human subjects, with documented improvements in skin density and photoaged skin appearance in several controlled trials.
Key References
For research reference only. All information pertains to preclinical or published human trial data. Not intended as medical advice. This product is for research use only.
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