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Cognitive & Nootropic · 10mg
Janoshik-tested · 10 vials per kit
Semax is a synthetic analog of ACTH(4-7) studied in preclinical and clinical research for its neuroprotective and cognitive-enhancing properties. Research has examined its potential to improve attention, memory, and learning while promoting neurorepair and adaptability to hypoxia and cerebral ischaemia. Studies have also explored its antioxidant, anti-inflammatory, and immunomodulatory effects, and potential in cerebrovascular diseases including stroke and Alzheimer disease.
≥98%
Purity
Lyophilised
Format
2–3 wks
Arrival
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Chemical Properties
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Research Use Only — Disclaimer
This product is intended solely as a research chemical for laboratory and scientific study purposes only. It is not approved by the TGA or any regulatory body for human or animal consumption, therapeutic use, or clinical application. The information provided on this website is for educational purposes only. Handling must be limited to suitably qualified professionals operating within applicable laws and regulations. This product is not classified as a drug, food, cosmetic, or medicinal product and must not be used or labelled as such. By purchasing, you confirm you are a qualified research professional and accept full responsibility for compliance with all relevant laws in your jurisdiction.
Semax
ACTH(4-7) Pro-Gly-Pro
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment of adrenocorticotropic hormone. The MEHF sequence corresponds to ACTH(4-7), while the C-terminal PGP improves metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it is registered in Russia for use in ischaemic stroke, transient ischaemic attack, and cognitive deficit. NA-Semax (N-acetyl Semax) is a modified form with enhanced stability studied for nasal delivery.
Semax markedly increases BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) mRNA and protein levels in hippocampal and prefrontal cortical tissue. It also modulates gene expression in the serotonin, dopamine, and GABA systems and activates NO-synthase pathways contributing to cerebroprotection. Unlike ACTH itself, Semax does not activate adrenocortical stress responses due to its truncation at position 7.
Clinical studies in Russia have examined Semax in acute ischaemic stroke (reduction in neurological deficit), perinatal hypoxia, optic nerve disease, and attention deficit disorder. Nootropic applications studied include enhanced sustained attention, working memory under stress, and cognitive performance in healthy subjects. Immunomodulatory effects including regulation of NK cell activity have also been described.
Key References
For research reference only. All information pertains to preclinical or published human trial data. Not intended as medical advice. This product is for research use only.
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