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Regenerative & Anti-Aging · 10mg
Janoshik-tested · 10 vials per kit
Snap-8 is a synthetic octapeptide studied in preclinical research for its neuromuscular and skin-targeted properties. Research has examined its potential to inhibit neurotransmitter release to reduce facial muscle contractions and alleviate wrinkles, promote collagen production through cellular signaling, and serve as a research model for SNAP-25 regulation in neurotransmitter release studies. Studies have explored potential in neurodegenerative disease models.
≥98%
Purity
Lyophilised
Format
2–3 wks
Arrival
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Chemical Properties
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Research Use Only — Disclaimer
This product is intended solely as a research chemical for laboratory and scientific study purposes only. It is not approved by the TGA or any regulatory body for human or animal consumption, therapeutic use, or clinical application. The information provided on this website is for educational purposes only. Handling must be limited to suitably qualified professionals operating within applicable laws and regulations. This product is not classified as a drug, food, cosmetic, or medicinal product and must not be used or labelled as such. By purchasing, you confirm you are a qualified research professional and accept full responsibility for compliance with all relevant laws in your jurisdiction.
Snap-8
Acetyl Octapeptide-3
Snap-8 (INCI: Acetyl Octapeptide-3) is a synthetic octapeptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) designed as an alternative to botulinum toxin for cosmetic research. It corresponds to the N-terminus of SNAP-25 (synaptosomal-associated protein of 25 kDa) — a key component of the SNARE protein complex responsible for neurotransmitter vesicle fusion at neuromuscular junctions.
Snap-8 competes with endogenous SNAP-25 for incorporation into the SNARE complex at neuromuscular junctions in facial expression muscles, partially inhibiting acetylcholine vesicle fusion without cleaving SNARE proteins (the mechanism of botulinum toxin). This competitively reduces acetylcholine release and attenuates muscle contraction intensity, particularly in muscles responsible for repetitive expressions that generate dynamic wrinkles. The effect is dose-dependent and fully reversible.
In vitro studies using neuronal cell preparations demonstrate that Snap-8 reduces acetylcholine release by approximately 36% at relevant concentrations — comparable mechanistically to botulinum toxin A but via competitive inhibition rather than SNARE cleavage. Human clinical studies have shown statistically significant reduction in the depth of forehead wrinkles compared to vehicle control. Research continues into optimal formulation for topical delivery.
Key References
For research reference only. All information pertains to preclinical or published human trial data. Not intended as medical advice. This product is for research use only.
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