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Tissue Repair & Recovery · 20mg
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Janoshik-tested · 10 vials per kit
Thymulin is a thymic nonapeptide studied in preclinical research for its immune-modulating properties. Research has examined its potential to regulate T-cell maturation and function, modulate inflammatory cytokine balance, and support immune system calibration in models of immune deficiency and inflammatory conditions.
≥98%
Purity
Lyophilised
Format
2–3 wks
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Research Use Only — Disclaimer
This product is intended solely as a research chemical for laboratory and scientific study purposes only. It is not approved by the TGA or any regulatory body for human or animal consumption, therapeutic use, or clinical application. The information provided on this website is for educational purposes only. Handling must be limited to suitably qualified professionals operating within applicable laws and regulations. This product is not classified as a drug, food, cosmetic, or medicinal product and must not be used or labelled as such. By purchasing, you confirm you are a qualified research professional and accept full responsibility for compliance with all relevant laws in your jurisdiction.
Thymulin
Facteur Thymique Sérique (FTS)
Thymulin (facteur thymique sérique, FTS) is a zinc-dependent nonapeptide hormone produced exclusively by thymic epithelial cells. Isolated by Bach et al. in 1977, it is the smallest known thymic peptide retaining direct immunomodulatory activity at nanomolar concentrations. Critically, biological activity requires chelation of a Zn2+ ion — apothymulin (zinc-free) is completely inactive. Serum thymulin levels decline sharply with age, correlating with immunosenescence.
The zinc-thymulin complex interacts with specific receptors on immature T-lymphocytes (thymocytes), triggering cAMP-mediated intracellular cascades that drive differentiation into mature T-cell subtypes (helper CD4+, cytotoxic CD8+, regulatory Treg). Thymulin upregulates T-cell surface markers (Thy-1, Lyt antigens), enhances natural killer (NK) cell and cytotoxic T-cell activity, and regulates IL-2 production. It can partially reverse age-related T-cell deficits when administered to aged animals.
Research has shown thymulin can restore immune competence in aged, zinc-deficient, and immunocompromised models. Applications include age-related immunosenescence, rheumatoid arthritis (anti-inflammatory T-reg induction), viral infection models, and correction of zinc-deficiency-driven immune dysfunction. Interestingly, recombinant thymulin fused to erythropoietin (metFts-EPO) is under investigation for spinal cord injury.
Key References
For research reference only. All information pertains to preclinical or published human trial data. Not intended as medical advice. This product is for research use only.
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