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Regenerative & Anti-Aging · 10mg
Janoshik-tested · 10 vials per kit
Humanin is a small mitochondria-derived peptide encoded within the mitochondrial 16S rRNA gene, studied in preclinical research for its cytoprotective and anti-apoptotic properties. Research has examined its potential to protect neurons from amyloid-beta toxicity, reduce apoptosis, modulate insulin sensitivity, and exhibit anti-inflammatory effects. Studies have explored applications in neurodegeneration, metabolic disease, and aging models.
≥98%
Purity
Lyophilised
Format
2–3 wks
Arrival
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Research Use Only — Disclaimer
This product is intended solely as a research chemical for laboratory and scientific study purposes only. It is not approved by the TGA or any regulatory body for human or animal consumption, therapeutic use, or clinical application. The information provided on this website is for educational purposes only. Handling must be limited to suitably qualified professionals operating within applicable laws and regulations. This product is not classified as a drug, food, cosmetic, or medicinal product and must not be used or labelled as such. By purchasing, you confirm you are a qualified research professional and accept full responsibility for compliance with all relevant laws in your jurisdiction.
Humanin
Mitochondria-Derived Neuroprotective Peptide
Humanin is a 21-amino-acid mitochondria-derived peptide (MDP) encoded in the 16S rRNA gene of the mitochondrial genome. Discovered in 2001 by Hashimoto et al. from a cDNA library of surviving neurons in an Alzheimer's disease patient's occipital lobe, it was the first peptide shown to protect neurons from Alzheimer's disease-related neurodegeneration. Circulating humanin levels decline with age, correlating with age-related disease risk.
Humanin acts via multiple receptor systems: the heterotrimeric CNTFR/WSX-1/gp130 complex (a member of the IL-6 cytokine receptor family) which activates JAK/STAT3 signalling; and formyl peptide receptor-like 1 (FPRL1) at lower affinity. These interactions activate PI3K/Akt and MAPK survival pathways. Intracellularly, humanin directly binds Bax and prevents its translocation to mitochondria, blocking the intrinsic apoptotic cascade independently of receptor signalling.
Neuroprotection (protection against Aβ-induced apoptosis, ischaemia, and various neurotoxins), anti-apoptotic activity across multiple cell types, metabolic wellness (interactions with IGFBP-3 to modulate IGF-1 bioavailability and insulin sensitivity), cardiovascular protection (reduced cardiomyocyte apoptosis in ischaemia models), and mitochondrial function. Also studied as a longevity biomarker — centenarians have higher circulating humanin levels.
Key References
For research reference only. All information pertains to preclinical or published human trial data. Not intended as medical advice. This product is for research use only.
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